Deux réunions de thèse sont prévues à Strasbourg:
– le 25 juin 2015 de 14:00 à 16h00
– le 30 juin 2015 de 14:00 à 16h00
D’autres dates seront prévues ultérieurement. Pour vous inscrire, veuillez cliquer ici
Deux réunions de thèse sont prévues à Strasbourg:
– le 25 juin 2015 de 14:00 à 16h00
– le 30 juin 2015 de 14:00 à 16h00
D’autres dates seront prévues ultérieurement. Pour vous inscrire, veuillez cliquer ici
Le prochain séminaire de psychiatrie aura lieu vendredi 26 juin 2015 de 9h à 16h en salle 211 du forum.
Amoxicillin once or twice-daily as effective as three-times-daily dosing for acute otitis media
Clinical question | How effective are once or twice-daily doses of amoxicillin, with or without clavulanate, for the treatment of acute otitis media in children aged 12 years or less? |
Bottom line | Treating acute otitis media (AOM) with either once/ twice-daily or 3-times-daily amoxicillin, with or without clavulanate, had the same results, including adverse events such as diarrhoea and skin reactions. The outcome measures were clinical cure rates in terms of resolution of otalgia and fever at the end of antibiotic therapy (days 7–15), middle ear effusion during therapy, and clinical cure rates post-treatment (1–3 months) in terms of resolution of middle ear infection and AOM complications |
Caveat | All of the included studies had an unclear risk of bias for allocation concealment. Three studies had an unclear risk of bias for randomisation, as they did not describe the details of randomisation sequence generation or methods to conceal allocation. |
Context | Amoxicillin, with or without clavulanate, is frequently prescribed as a treatment of choice for AOM. The conventional recommendation is either 3 or 4 doses daily |
Cochrane Systematic Review | Thanaviratananich S et al. Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media. Cochrane Reviews, 2013, Issue 12. Art. No.: CD014975.DOI: 10.1002/14651858. CD014975.pub3. This review contains 5 studies involving 1601 participants. |
Pearls No. 454 March 2015, written by Brian R McAvoy |